Reversal effect of Zhigancao decoction on myocardial fibrosis in a rapid pacing-induced atrial fibrillation model in New Zealand rabbits

Reversal effect of Zhigancao decoction on myocardial fibrosis in a rapid pacing-induced atrial fibrillation model in New Zealand rabbits

Blog Article

Objective To evaluate icon track bar f250 the effect of Zhigancao decoction on reversal of right atrial myocardial fibrosis after rapid atrial pacing (RAP)-induced atrial fibrillation (AF).Methods New Zealand white rabbits were randomly divided into four groups: sham operation group (Group A: implanted electrodes, no RAP), pacing group (Group B: RAP-induced AF), Zhigancao soup water decoction Yin group (Group C: RAP-induced AF followed by Zhigancao soup Yin prescription twice a day for 30 days), and Zhigancao soup group (Group D: RAP-induced AF followed by Zhigancao water decoction twice a day for 30 days).The atrial myocardium was then examined for myocardial fibrosis by Masson staining, and protein expression of matrix metalloproteinase-9 (MMP-9) was immunohistochemically assessed.The right atrial appendage tissue field action potential duration (fAPD) was measured by microelectrode arrays.

Results RAP successfully induced AF.Myocardial fibrosis was more severe in Groups B and C and less severe in Group D.Protein expression of MMP-9 was strongly positive in Groups B and C and weakly positive in Group D.The fAPD was significantly decreased in Groups B and C, but the decrease in Group D was not significant.

Conclusion Zhigancao decoction trailmaster challenger 200x can reverse AF-induced myocardial fibrosis in rabbits and shorten the fAPD.